Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs
US5625043A · kind A · utility
13Cited by
10References
19Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Feb 27, 1995 |
| Grant date | Apr 29, 1997 |
| Priority date | — |
| Expiry date | Feb 27, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the disclosure involve synthesis steps wherein a hydroxyl group on a sugar moiety to be added is blocked with a halo-substituted alkyl group during the process of adding it to an anthracycline ring compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.