Preparation of colloidal aqueous solutions of active substances of low solubility

US5626864A · kind A · utility

Assignee

• Knoll, Inc. · DE

Inventors

• Joerg Rosenberg · Ellerstadt, DE
• Cynthia Romerdahl · Wayland, US
• Juergen Heberger · Schifferstadt, DE

Key dates

• Filing date: Aug 2, 1995
• Grant date: May 6, 1997
• Expiry date: Aug 2, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process with whose aid active substances of low solubility can be processed together with phospholipids to give a homogeneous solution, which comprises PA1 a) mixing the active substance with a phospholipid, PA1 b) adding an acidic aqueous solution of a carbohydrate to the residue at elevated temperature, and stirring this mixture at elevated temperature until a homogeneous colloidal solution is produced, and PA1 c) cooling the solution, and adjusting to a pH of 4-5 and sterilizing is described.