Composition and methods for sterilizing dialyzers
US5628959A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 3, 1995 |
| Grant date | May 13, 1997 |
| Priority date | — |
| Expiry date | Apr 3, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2/18
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Compositions and methods are provided for sterilizing hemodialysis apparatus, particularly for reprocessing dialyzers in a manner that minimizes membrane perforations. The compositions contain a protic acid and a metal chlorite, and have a pH of at least about 2.3 and no greater than 4.2. Methods of this invention include contacting both the blood side and the dialysate side of a dialysis membrane with the composition, followed by first displacing the composition on the dialysate side with water or an aqueous alkali buffer having a pH in excess of about 6.0, such that the pH of the composition on the blood side of the dialysis membrane increases to at least about 5.0. The composition on the blood side is then displaced with saline. In a further embodiment, the composition has a pH ranging from 3.3 to 4.2, and the amount of chlorite ion in the form of chlorous acid ranges from 0.5% to 5.0% by weight of the total amount of chlorite ion in the composition. In this embodiment, the composition may be employed without associated membrane degradation by using existing hemodialysis set-up techniques, except that dialysate displacement on the dialysate side precedes saline displacement of b…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.