Calcineurin inhibitory compounds and anchoring protein

US5629163A · kind A · utility

Assignees

• ICOS CORPORATION · US
• State of Oregon, acting by and through the Oregon State Board of Higher Education on behalf of the Oregon Health Sciences University · US

Inventors

• John D. Scott · Wixom, US
• Vincent M. Coghlan · Portland, US
• Monique L. Howard · Seattle, US
• William Michael GALLATIN · Mercer Island, US

Key dates

• Filing date: May 30, 1995
• Grant date: May 13, 1997
• Expiry date: May 30, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/16
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA.