Granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof

US5629283A · kind A · utility

Assignee

• AMRAD Corporation Limited · AU

Inventors

• Nicos A. Nicola · Melbourne, AU
• Nicholas Martin Gough · Melbourne, AU
• David Gearing · Melbourne, AU
• Donald Metcalf · Melbourne, AU
• Julie Ann King · Melbourne, AU

Key dates

• Filing date: Nov 23, 1994
• Grant date: May 13, 1997
• Expiry date: Nov 23, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a recombinant or synthetic receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) and biochemical and/or biological equivalents, homologues, or derivatives thereof. The GM-CSF receptor is useful inter alia in treatment and diagnosis of GM-CSF related diseases, and in screening of agonists and antagonists of binding of GM-CSF to its cell-bound receptors. The invention further provides nucleic acid sequences encoding GM-CSF receptor, recombinant DNA molecules comprising these sequences, and transformed hosts carrying the recombinant DNA molecules, as well as antibodies directed against GM-CSF receptor, and pharmaceutical compositions comprising either the GM-CSF receptor or antibodies thereto.