Cyclic peptide antifungal agents
US5629290A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 8, 1996 |
| Grant date | May 13, 1997 |
| Priority date | — |
| Expiry date | Mar 8, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I ##STR1## where: R', R", R'", R.sup.x1, R.sup.x2, R.sup.y1, R.sup.y2, R.sup.y3, R.sup.y4, and R.sup.0 are as defined hereinabove; and PA1 R.sup.2 is ##STR2## R.sup.3 is ##STR3## R.sup.3a is C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy; R.sup.3b and R.sup.3c are independently phenyl or naphthyl; PA1 R.sup.3d is C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or --O --(CH.sub.2).sub.m -[O--(CH.sub.2).sub.n ].sub.p --O--(C.sub.1 -C.sub.12 alkyl); PA1 m is 2, 3 or 4; PA1 n is 2, 3 or 4; PA1 p is 0 or 1; or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.