N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents
US5629343A · kind A · utility
2Cited by
1References
13Claims
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Key dates
| Filing date | Feb 23, 1995 |
| Grant date | May 13, 1997 |
| Priority date | — |
| Expiry date | Feb 23, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K41/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as arthritis, periodontal disease, corneal ulceration, are described. For example, N-(2-thiomethyl-4-phenyl-butanoyl)-L-leucinamide was prepared and its inhibitory activity against stromelysin was tested in vitro.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.