Preparation of .alpha.-aryl .gamma.-butyrolactones
US5629432A · kind A · utility
2Cited by
0References
5Claims
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Assignee
Inventor
Key dates
| Filing date | May 16, 1995 |
| Grant date | May 13, 1997 |
| Priority date | — |
| Expiry date | May 16, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D315/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This appliciation discloses a process for preparing a lactone of general formula (I), where R is an optionally substituted phenyl group or an optionally substituted mono- or bicyclic heteroaryl radical which process comprises reacting an anion of a malonate of formula (II) with an ethylene compound of formula (III) Y--CH.sub.2 --CH.sub.2 OZ, to give a compound of formula (IV) and hydrolysing the compound of formula (IV) to give a lactone of formula (I). The lactones are of use as intermediates for preparing 5-HT.sub.1A binding agents. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.