Phosphorylated polyazamacrocyclic compounds for complexation of metal ions
US5630997A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 8, 1994 |
| Grant date | May 20, 1997 |
| Priority date | — |
| Expiry date | Nov 8, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has the formula ##STR1## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p +q=y; PA0 y is 3 or 4; PA0 R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ; PA0 R.sup.1 is H or CH.sub.3 ; PA0 R.sup.2 is C.sub.n H.sub.1+2n ; PA0 n is 4 to 6; PA0 z is 1 to 3. In one important embodiment, this compound may be complexed with a metal to be a polyazamacrocyclic compound-metal complex having the formula ##STR2## where r is 2 or 3; and PA0 M is a metal ion, including a lanthanide, a heavy metal, or a radionuclide metal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.