Immunotherapy protocol of culturing leukocytes in the presence of interleukin-2 in a hollow fiber cartridge
US5631006A · kind A · utility
43Cited by
16References
5Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | May 20, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/23
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An immunotherapy protocol in which leukocytes are cultured in the presence of interleukin-2 in a hollow fiber cartridge perfusion system for at least four days to achieve a harvest yield of at least 100% of leukocytes with respect to the number of cells initially present in the hollow cartridge, and where the leukocytes have a lytic activity at least equal to that of cells grown in a static culturing system and where the lytic activity of the cells following the culture period in the hollow fiber is at least equal to cells grown in a static culturing system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.