Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5631236A · kind A · utility
127Cited by
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6Claims
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Key dates
| Filing date | Aug 26, 1993 |
| Grant date | May 20, 1997 |
| Priority date | — |
| Expiry date | Aug 26, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel method of treating localized solid tumors and papilloma in an individual. The method comprises introducing a recombinant adenoviral vector containing the herpes simplex virus-thymidine kinase gene. Subsequently, a prodrug, such as the drug ganciclovir, is administered to the individual. The methods of the present invention may be used to treat several different types of cancers and papillomas, including colon carcinoma, prostate cancer, breast cancer, lung cancer, melanoma, hepatoma, brain and head and neck cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.