Method of effecting immunosuppression by administering carbocyclic adenosine analogs
US5631258A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 26, 1995 |
| Grant date | May 20, 1997 |
| Priority date | — |
| Expiry date | Apr 26, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to methods of effecting immunosuppression and inhibiting tumor necrosis factor .alpha. in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of a compound of the formula ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent, PA1 Y.sub.3 is N, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group, PA1 Q is NH.sub.2, halogen or hydrogen, and PA1 Z is hydrogen, halogen, or NH.sub.2 ; or a pharmaceutically-acceptable salt thereof. Also presented are pharmaceutical compositions comprising compounds of the same formula.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.