Xanthine epoxides as A.sub.1 adenosine receptor agonists and antagonists

US5631260A · kind A · utility

Assignee

• University of Florida Research Foundation, INC. · US

Inventors

• Luiz Belardinelli · Palo Alto, US
• Ray Olsson · Hammarland, FI
• Stephen R. Baker · Camberley, GB
• Peter Scammells · Geelong, AU
• Peter G. Milner · Los Altos Hills, US
• J urg R. Pfister · Los Altos, US
• George F. Schreiner · Los Altos Hills, US

Key dates

• Filing date: Oct 28, 1994
• Grant date: May 20, 1997
• Expiry date: Oct 28, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Xanthine derivatives, and compositions comprising those compounds, are potent selective antagonists of adenosine receptors. The derivatives and compositions are used to treat conditions, including certain cardiac arrhythmias. The compounds, specifically, are C-8 epoxide derivatives of xanthine having the general formulae of: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and can be H or an alkyl group of 1-4 carbons, and n=0-4; and ##STR2## wherein R.sub.1 and R.sub.2 are the same or different, and can be H or an alkyl group of 1-4 carbons, R.sub.3 is either O or (CH.sub.2).sub.1-4, and n=0-4.