Preparation of amino acid-substituted benzoylguanidines as diagnostic agents

US5631293A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinz-Werner Kleemann · Bischofsheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Andreas Weichert · Egelsbach, DE
• Wolfgang Scholz · Beverly, US
• Udo Albus · Florstadt, DE

Key dates

• Filing date: Sep 8, 1995
• Grant date: May 20, 1997
• Expiry date: Sep 8, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Amino acid-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent and a medicament containing them Benzoylguanidines of the formula I ##STR1## in which the radicals R(1) to R(5) have the meanings given in the description, are described. They are prepared by reacting a compound of the formula II ##STR2## in which R(1) to R(5) and L have the meanings given in the description, with guanidine. The compound I is suitable for the preparation of cardiovascular medicaments.