Drugs containing S(+)-ibuprofen

US5631296A · kind A · utility

Assignee

• Spirig AG, Pharmazeutische Praeparate · CH

Inventors

• Gerd Birrenbach · Kappel, CH
• Rolf-Dieter Juch · Olten, CH

Key dates

• Filing date: Sep 16, 1994
• Grant date: May 20, 1997
• Expiry date: Sep 16, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Rapid-release S(+)-ibuprofen pellets are proposed whose bioavailability is comparable to that of commercially available racemate formulations. The rapid release of the active substance is promoted by using small amounts of basic inorganic salts, preferably sodium carbonate, or dilute alkali metal hydroxide solutions. Pellets with an active substance content of 90-99% by weight are obtainable in this way. The pellets are suitable for the application of coatings. Pellets with a protective coating can be compressed directly to tablets in this form and with small amounts of suitable tableting adjuncts. The use of the pharmacologically active S(+)-ibuprofen and of the small amounts of adjuncts required makes it possible to prepare compact pharmaceutical forms.