5'-O-Dans EOC modified nucleosides and methods for preparing same

US5631362A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Pfleiderer · Konstanz, DE
• Frank Bergmann · Iffeldorf, DE

Key dates

• Filing date: May 9, 1995
• Grant date: May 20, 1997
• Expiry date: May 9, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Dansylethoxycarbonyl (Dans-EOC) groups which can be employed as base-labile 5'hydroxyl protective groups in chemical oligonucleotide synthesis are disclosed. These groups allow the preparation of a compound of the formula (I) ##STR1## which comprises reacting the compound of the formula (II) ##STR2## with a chlorocarbonyl donor.