Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5631365A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 9, 1994 |
| Grant date | May 20, 1997 |
| Priority date | — |
| Expiry date | Jun 9, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing compounds of the formula ##STR1## wherein R and R.sup.2 are independently --OH, --O(lower alkyl) or --0-benzyl and the remaining variables are as defined in the specification, comprising PA1 (a) treating with a strong base in an anhydrous organic solvent a lactone of the formula ##STR2## respectively, wherein Ar.sup.10 is Ar.sup.1 or a suitably protected hydroxy- or amino-substituted aryl, and R' and R.sup.2' are R and R.sup.2 as defined above or are suitably protected hydroxy groups; PA1 (b) reacting a product of step (a) with an imine of the formula ##STR3## wherein Ar.sup.20 and Ar.sup.30 are Ar.sup.2 or Ar.sup.3 or suitably protected hydroxy- or amino-substituted aryl; PA1 c) quenching the reaction with an acid; and PA1 d) removing protecting groups as necssary.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.