Method for the preparation of N-substituted 4-ketoproline derivatives

US5631385A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Karlheinz Drauz · Alzenau, DE
• Matthias Kottenhahn · Alzenau, DE
• Klaus Stingl · Alzenau, DE

Key dates

• Filing date: Jun 27, 1996
• Grant date: May 20, 1997
• Expiry date: Jun 27, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Method for the preparation of N-protected 4-ketoproline derivatives of formula I ##STR1## by oxidation of the corresponding N-protected 4-hydroxyproline derivatives of ##STR2## using the system TEMPO (2,2,6,6-tetramethylpiperidinyl oxy free radical)/NaOCl.