Inhibitors of protein farnesyltransferase and squalene synthase
US5631401A · kind A · utility
16Cited by
9References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 24, 1995 |
| Grant date | May 20, 1997 |
| Priority date | — |
| Expiry date | Jan 24, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.