Immunogens and the use thereof for obtaining antibodies against HbA.sub.1c

US5632993A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Christian Klein · Iffeldorf, DE
• Christa Hubner-Parajsz · Tutzing, DE
• Hans-Georg Batz · Tutzing, DE
• Wolfgang Rollinger · Polling, DE
• Ulrich Essig · Wissen, DE
• Lorenz Kerscher · Penzberg, DE

Key dates

• Filing date: May 16, 1995
• Grant date: May 27, 1997
• Expiry date: May 16, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides immunogens for obtaining HbA.sub.1c -specific antibodies, which immunogens have the general formula: ##STR1## wherein M is 1 to 40, T is a carrier protein and A is a spacer which has a chain length of 10 to 20 atoms and has the general formula: ##STR2## wherein X is a sulphur atom or au --NH-- group, n is 1 to 4 and B is an organic radical which contains a succinimide group. The present invention also provides a process for obtaining antibodies which specifically bind glycosylated haemoglobin, wherein an immunogen of general formula (I) is injected into an organism capable of antibody formation and the antibodies are then obtained in known manner. These antibodies can be used for determining HbA.sub.1c in body fluids.