Process for systhesizing cyclic peptides
US5633346A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 25, 1995 |
| Grant date | May 27, 1997 |
| Priority date | — |
| Expiry date | May 25, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process is provided for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. The cyclic peptide is represented by the following formula (I): ##STR1## wherein X1, X2, X4 and X7 are independently N-methyl-.alpha.-amino acid or .alpha.-hydroxy acid, PA1 provided that at least one of X1, X2, X4 and X7 is an .alpha.-hydroxy acid; PA1 X3, X6 and X8 are independently .alpha.-amino acid; PA1 X5 is a cyclic amino acid; PA1 X9 is an N-methyl-.alpha.-amino acid or .alpha.-hydroxy acid substituted by a hydroxy group; PA1 and the dotted lines represent intramolecular hydrogen bonds. The process includes cyclizing a corresponding linear peptide between X5 and X6 via a peptide bond.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.