Targeting protein-diagnostic/therapeutic agent conjugates having Schiff base linkages
US5633351A · kind A · utility
14Cited by
15References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 1, 1994 |
| Grant date | May 27, 1997 |
| Priority date | — |
| Expiry date | Nov 1, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Targeting protein-diagnostic/therapeutic agent conjugates joined by stabilized Schiff base linkages are disclosed. Schiff base linkage of targeting protein and agent is accomplished without exposure of the targeting protein to harsh oxidizing or reducing conditions. The cleavable, heterobifunctional linkers that are described provide certain advantages relating to in vivo administration of targeting protein conjugates, including controlled release of active agent at a target site.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.