Patent · US Expired

Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

US5635157A · kind A · utility

6Cited by

9References

17Claims

0Family size

Inventors

Ronnie C. Mease · Fairfax, US
Kathryn L. Kolsky · Mina, US
Leonard F. Mausner · Port Jefferson, US
Suresh C. Srivastava · Port Jefferson, US

Key dates

Filing date	Oct 6, 1993
Grant date	Jun 3, 1997
Priority date	—
Expiry date	Oct 6, 2013

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/16
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.