Dihydropyridine npy antagonists: piperazine derivatives

US5635503A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Graham S. Poindexter · Old Saybrook, US
• Marc Bruce · Wallingford, US
• Graham Johnson · Madison, US
• Michael R. Kozlowski · Palo Alto, US
• Karen LeBoulluec · Wallingford, US
• Ivo Monkovic · Candiac, CA
• Ramakrishna Seethala · Plainsboro, US
• Charles P. Sloan · Wallingford, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jun 3, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.