Method of forming multiple glycosidic linkages in a single step
US5635612A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 18, 1994 |
| Grant date | Jun 3, 1997 |
| Priority date | — |
| Expiry date | Feb 18, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage of the discovery that the relative reactivity of glycoside residues containing anomeric sulfoxides and nucleophilic functional groups can be controlled. In another aspect of the invention, the reactivity of activated anomeric sugar sulfoxides is utilized in a solid phase method for the formation of glycosidic linkages. The methods disclosed may be applied to the preparation of specific oligosaccharides and other glycoconjugates, as well as to the preparation of glycosidic libraries comprising mixtures of various oligosaccharides, including glycoconjugates, which can be screened for biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.