Biologically active compounds and methods of constructing and using the same

US5637677A · kind A · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• The Wistar Institute · US
• COLORADO STATE UNIVERSITY · US

Inventors

• Mark I. Greene · Levittown, US
• William V. Williams · Havertown, US
• David B. Weiner · Yeadon, US
• Jeffrey A. Cohen · Blue Bell, US
• Thomas Kieber-Emmons · Little Rock, US
• Robert M. Williams · Chesterfield, US

Key dates

• Filing date: Sep 3, 1992
• Grant date: Jun 10, 1997
• Expiry date: Sep 3, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein or which block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.