Process for preparing optically active amide derivatives
US5637701A · kind A · utility
4Cited by
3References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 11, 1995 |
| Grant date | Jun 10, 1997 |
| Priority date | — |
| Expiry date | Apr 11, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/145
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel asymmetric synthesis is provided for preparing optically active amides of formula (A) and their salts. ##STR1## In the formula, X represent --N-- or --CH--, R represents a mono or bicyclic aryl or heteroaryl group, R.sup.1 is an aryl or heteroaryl radical, and R.sup.2 and R.sup.3 have specified meanings. The products are useful as 5-HT.sub.1A antagonists. Novel diesters of formula D useful as intermediates in the process are also disclosed. ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.