Method for evaluating immunogenicity
US5639440A · kind A · utility
3Cited by
3References
11Claims
0Family size
Inventor
Key dates
| Filing date | Apr 25, 1995 |
| Grant date | Jun 17, 1997 |
| Priority date | — |
| Expiry date | Apr 25, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biological effects of agents for diagnostic or therapeutic use are evaluated by administration of the agents to transgenic animals which are transformed with heterologous DNA and which are immune tolerant to the expression product of the heterologous DNA. In a further embodiment, preparations that are immunogenic in the transgenic animal model are purified by reverse immunoaffinity chromatography on antibody obtained from responding transgenic animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.