Process for the production of antibodies

US5639457A · kind A · utility

Assignee

• Gottfried Brem · DE

Inventors

• Gottfried Brem · Markt Indersdorf, DE
• Ulrich Weidle · Hersbruck, DE

Key dates

• Filing date: Nov 15, 1994
• Grant date: Jun 17, 1997
• Expiry date: Nov 15, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01K2267/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Process for the production of proteins with antibody activity in which one or several DNA sequences coding for this protein are introduced into the male pronucleus of a fertilized ovum of a pig or rabbit by microinjection, the ova are implanted in the oviduct of a pig or rabbit, the offspring are bred and the protein with antibody activity is isolated from their serum in the usual way whereby the DNA sequences used for the microinjection are free of bacterial foreign sequences, and are preferably used with immunoglobulin promoter and enhancer sequences.