Hepatitis B vaccine
US5639637A · kind A · utility
5Cited by
1References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1994 |
| Grant date | Jun 17, 1997 |
| Priority date | — |
| Expiry date | Nov 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2730/10122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.