Increased enantioselectivity of lipase catalyzed transesterification of alkynols with vinyl esters
US5639662A · kind A · utility
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Key dates
| Filing date | Sep 18, 1995 |
| Grant date | Jun 17, 1997 |
| Priority date | — |
| Expiry date | Sep 18, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/004
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Process for enhancement of enantioselectivity in the enzymatic separation of (R)- and (S)-enantiomers of an asymmetric alkynol, a lipase and in the presence of at least one vinyl ester, in which the acid component has at least 4 C atoms, an organic solvent and with the addition of water. Also disclosed is a process for enhancement of enantioselectivity in the enzymatic separation of (R)- and (S)-enantiomers of an alcohol with the aid of the abovementioned vinyl ester under addition of a second vinyl ester having at least 2 C atoms less in the alkyl chain than the vinyl ester used as esterifying agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.