Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis
US5639744A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 4, 1995 |
| Grant date | Jun 17, 1997 |
| Priority date | — |
| Expiry date | Apr 4, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J43/003
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An amide of formula ##STR1## and its pharmacologically acceptable organic or inorganic salt shows a metabolic stability, both enteric and hepatic, greater than that of the corresponding bile acids conjugated with glycine or taurine physiologically present in the enterohepatic circulation. The pharmacological activity of the compounds of formula I or their pharmacologically acceptable organic or inorganic salt makes the use effective for the therapy of biliary calculosis from cholesterol and in every pathology caused by cholestasis like chronic hepatitis from cholestasis, primitive biliary cirrhosis and juvenile hepatopathy associated with cystic fibrosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.