Indoletetralins having dopaminergic activity

US5639778A · kind A · utility

Assignee

• Pharmacia & Upjohn Company LLC · US

Inventors

• Bengt R. Andersson · Göteborg, SE
• Per A. E. Carlsson · Göteborg, SE
• Lars O. Hansson · Gothenburg, SE
• Clas Sonesson · Lindome, SE
• N. Peter Stjernlof · Mölndal, SE
• Kjell A. I. Svensson · Alingsås, SE
• R. Nicholas Waters · Göteborg, SE
• Susanne R. Haadsma-Svensson · Portage, US

Key dates

• Filing date: Sep 7, 1995
• Grant date: Jun 17, 1997
• Expiry date: Sep 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R.sub.3 and X and Y form (a), or X is R.sub.3 and Y and Z form (a) or (b); R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, --CH.sub.2 --C.sub.3-7 cycloalkyl, phenyl (optionally substituted with halogen or C.sub.1-6 alkyl), -thiophenyl (optionally substituted with halogen or C.sub.1-6 alkyl), or C.sub.1-6 alkyl phenyl; R.sub.3 are independently hydrogen, halogen, --O--C.sub.1-6 alkyl or C.sub.1-6 alkyl; R.sub.4 is a valence bond, CH.sub.2 or oxygen; R.sub.5 and R.sub.6 are independently hydrogen, sulfur, --S--C.sub.1-6 alkyl, halogen, CON(R.sub.3).sub.2, --COCF.sub.3, --CO--C.sub.1-6 alkyl, --CO phenyl, oxygen, --CHO, CN except that when Y and Z form (b), R.sub.1 and R.sub.2 are hydrogen or a C.sub.1-6 alkyl and R.sub.3 is hydrogen, then at least one of R.sub.5 and R.sub.6 must be other than hydrogen. These compounds and derivatives thereof exhibit dopamine-receptor stimulating activity in mammals. ##STR1##