Carboxylate protective groups, a process for their preparation, their coupling to a functional group, and their use

US5639859A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Horst Kunz · Mainz, DE
• Gunther Braum · Wiesbaden, DE
• Peter Braun · Nieder-Olm, DE

Key dates

• Filing date: May 15, 1995
• Grant date: Jun 17, 1997
• Expiry date: May 15, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Carboxylate protective groups, a process for their preparation, their coupling to a funcitonal group, and their use Carboxylates of polar, hydrophilic alcohols of the formula ##STR1## in which R is an unbranched or branched organic radical which contains, as polar members between aliphatic or araliphatic hydrocarbon bridges, ether oxygens, amine nitrogen groups or a mixture of ether and amine groups which can be incorporated into a cyclic structure, where the total length does not exceed 20 members and where, in the case of polyethylene glycol [(CH.sub.2 --CH.sub.2 --O).sub.n ], n indicates the number of the members and is defined as any integer, and PA1 R' is an aliphatic or araliphatic radical which has at least one functional group, are suitable as protective groups since they can be introduced selectively into functional groups of organic compounds and eliminated specifically by lipases.