Nucleic acid molecules encoding novel parasitic helminth proteins
US5639876A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 19, 1993 |
| Grant date | Jun 17, 1997 |
| Priority date | — |
| Expiry date | Aug 19, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96402
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.