Method of assaying for an analyte using surface plasmon resonance
US5641640A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 29, 1994 |
| Grant date | Jun 24, 1997 |
| Priority date | — |
| Expiry date | Dec 29, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In a method of assaying for an analyte in a fluid sample, the presence of the analyte is detected by determining the resulting change in refractive index at a solid optical surface in contact with the sample, which change is caused by the analyte involving or influencing the binding or release of a refractive index enhancing species to or from, respectively, the optical surface, the refractive index of the refractive index enhancing species varying with wavelength. According to the invention, the determination comprises determining the variation with wavelength of the resulting change of refractive index, caused by the variation of refractive index with wavelength of the refractive index enhancing species, for a number of discrete wavelengths or for a continuous range of wavelengths. This variation is representative of the amount of analyte.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.