Transfection of lung via aerosolized transgene delivery
US5641662A · kind A · utility
150Cited by
12References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 10, 1993 |
| Grant date | Jun 24, 1997 |
| Priority date | — |
| Expiry date | Mar 10, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The invention provides a direct method for transforming pulmonary cells as a means for treating disorders of the lung as for providing a means for delivering substances systematically following expression in the lung.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.