Selective ligands of 5-HT.sub.1D -5-HT.sub.1B receptors derived from indolepiperazine which are useful medicaments

US5641779A · kind A · utility

Assignee

• PIERRE FABRE MÉDICAMENT · FR

Inventors

• Serge Halazy · Wolfisheim, FR
• Michel Perez · Castres, FR
• Michael Briley · Albi, FR

Key dates

• Filing date: Jun 29, 1995
• Grant date: Jun 24, 1997
• Expiry date: Jun 29, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds having the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a linear or branched alkyl radical or a phenyl, benzyl, cycloalkyl, polycycloalkyl, dibenzocycloalkyl, dibenzooxepine, dibenzoazepine, dibenzothiepine, benzopyrrolocycloalkyl, benzothienocycloalkyl or naphthyl radical, optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, aryl acyl, alkoxy and alkyl thio radicals. PA1 Z is C.dbd.O, SO.sub.2 or (CH.sub.2).sub.n in which n is between 1 and 5. PA1 R.sub.2 is a hydrogen atom, a linear or branched alkyl radical or a phenyl, benzyl, cycloalkyl, pyrrole, furan, pyridinyl or thiophenyl radical, optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, aryl, acyl, alkoxy and alkylthio radicals. PA1 R'.sub.2 is a hydrogen atom, a linear or branched alkyl radical or a phenyl radical. PA1 R.sub.3 is a hydrogen atom, a linear or branched alkyl radical or a benzyl or phenethyl radical. PA1 R.sub.4 is a hydrogen, chlorine, fluorine or bromine atom or a linear or branched alkyl radical. PA1 R.sub.5 is a hydrogen atom, a linear or branched alkyl radical or a benzyl …