Oxazoloquinolinone derivatives, their preparation and their therapeutic application as inhibitors of monoamine oxidase
US5641785A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 1995 |
| Grant date | Jun 24, 1997 |
| Priority date | — |
| Expiry date | Sep 1, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
3,3a,4,5-Tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one derivatives of formula (I) ##STR1## in which: n is 0 or 1, PA1 R.sub.1 represents a hydrogen atom or an ethenyl, methyl, ethyl, phenyl, hydroxymethyl or methoxymethyl group, and PA2 (i) R.sub.2 is a methyl, trifluoromethyl or cyano group, R.sub.3 is a hydrogen atom or a hydroxyl or benzyloxy group and R.sub.4 and R.sub.5 are hydrogen atoms, PA2 or (ii) R.sub.2 and R.sub.4 together form a --(CH.sub.2).sub.4 -- group, R.sub.3 is a hydroxyl group and R.sub.5 is a hydrogen atom, PA2 or (iii) R.sub.2 and R.sub.5 together form an --O--(CH.sub.2).sub.3 -- group, and R.sub.3 and R.sub.4 are hydrogen atoms, PA2 or (iv) R.sub.2 and R.sub.5 together form a --(CH.sub.2).sub.4 group, R.sub.3 is a hydroxyl group and R.sub.4 is a hydrogen atom, are useful as selective inhibitors of MAO-A or as mixed inhibitors of MAO-A and MAO-B.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.