High-flux hollow-fiber membrane with enhanced transport capability and process for making same
US5643452A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1994 |
| Grant date | Jul 1, 1997 |
| Priority date | — |
| Expiry date | Oct 21, 2014 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2325/36
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Semipermeable membranes are disclosed for purifying aqueous biological fluids. The membranes are particularly suitable for purifying extracorporeal blood via hemodialysis. The membranes, preferably configured as hollow fibers, are made from a hydrophilic polymeric material, preferably cellulose acetate. Features of the membranes include an ultrafiltration coefficient (K.sub.uF) of about 15 to about 55 mL/hr/mmHg/m.sup.2 (thus termed "high-flux" type membranes), a urea mass transfer coefficient (K.sub.oV (urea)) of at least 38.times.10.sup.-3 cm/min, and a ratio of K.sub.oV (urea)/K.sub.uF of at least 2.5.times.10.sup.-3. Hollow fibers of such membranes suitable for hemodialysis have a lumen diameter of about 175 to about 210 .mu.m and a wall thickness of about 10 to about 35 .mu.m. According to disclosed methods for making the membranes, a melt comprising about 32 to about 40% w/w cellulose acetate, about 5 to about 10% w/w glycerine, and about 50 to about 67% w/w polyethylene glycol is extruded to make hollow fibers; the fibers are cooled, cold-stretched, water-leached, and replasticized using a glycerine solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.