Patent · US Expired

O-acylated cyclosporins

US5643870A · kind A · utility

31Cited by

8References

11Claims

0Family size

Assignee

Sandoz AG · CH

Inventors

Johann Jakob Boelsterli · Buus, CH
Marcel K. Eberle · Riehen, CH
Reto Naef · Schlieren, CH
Trevor Payne · Arlesheim, CH

Key dates

Filing date	Feb 26, 1993
Grant date	Jul 1, 1997
Priority date	—
Expiry date	Feb 26, 2013

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A cyclosporin of the formula ##STR1## wherein A is a residue of the formula ##STR2## wherein R is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy or C.sub.1-3 alkylthio; halo-substituted-C.sub.1-3 alkyl, -C.sub.1-3 alkoxy or -C.sub.1-3 alkylthio; hydroxy-substituted-C.sub.1-3 alkyl, -C.sub.2-3 alkoxy or -C.sub.2-3 alkylthio; or amino or mono- or di-(C.sub.1-2 alkyl)-amino, PA0 X is oxygen or sulphur, PA0 --x--y-- is --CH.dbd.CH-- (trans) or --CH.sub.2 --CH.sub.2 --, PA1 B is -.alpha.Abu-, -Val-, -Thr- or -Nva- and PA1 Q is -(D)Ala-; -(D)Ser-; -[O-(2-hydroxyethyl)(D)Ser]-; or -[O-acyl(D)Ser]- or -[O-(2-acyloxy ethyl)(D)Ser]- in which the acyl residue is physiologically hydrolysable and acceptable, are useful in the topical treatment of asthma.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.