5-amino-4-hydroxyhexanoic acid derivatives

US5643878A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Guido Bold · Gipf-Oberfrick, CH
• Marc Lang · Mulhouse, FR
• Alexander Fassler · Macclesfield, GB
• Hans-Georg Capraro · Rheinfelden, CH
• Shripad S. Bhagwat · San Diego, US
• Peter Schneider · Königstein, DE
• Peter Hoogevest · Riehen, CH

Key dates

• Filing date: Mar 8, 1994
• Grant date: Jul 1, 1997
• Expiry date: Mar 8, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## or their hydroxy-protected derivatives, and compounds of formula I' ##STR2## wherein T is an acyl radical of formula Z ##STR3## wherein R.sup.z is unsubstituted or substituted hydrocarbyl wherein at least one carbon atom has been replaced by a hetero atom with the proviso that a hetero atom is not bonded directly to the carbonyl to which the radical R.sup.z is bonded, alkyl having two or more carbon atoms, lower alkenyl, lower alkynyl, aryl or unsubstituted or substituted amino, and wherein the radicals R.sub.1, B.sub.1, R.sub.2, R.sub.3, A.sub.1, A.sub.2 and NR.sub.4 R.sub.5 are as defined in the description, and precursors thereof, are described. The compounds have pharmaceutical activity, for example in the treatment of retroviral diseases, such as AIDS.