N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines

US5643893A · kind A · utility

Assignees

• Macronex, Inc. · US
• University of North Carolina · US

Inventors

• Bradley J. Benson · Chapel Hill, US
• Xiannong Chen · Athens, US
• George J. Cianciolo · Durham, US
• Jose-Luis Diaz · San Jose, US
• Khalid S. Ishaq · Chapel Hill, US
• Susan L. Morris-Natschke · Apex, US
• Ronald J. Uhing · Durham, US
• Henry Wong · Candiac, CA

Key dates

• Filing date: Jun 22, 1994
• Grant date: Jul 1, 1997
• Expiry date: Jun 22, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel N-substituted-(dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an bromoalkyl boronic acid with the purine, indole or pyrimidine base.