Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US5643939A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 16, 1994 |
| Grant date | Jul 1, 1997 |
| Priority date | — |
| Expiry date | Feb 16, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new use of, and method of treatment using, a compound selected from the group consisting essentially of compounds of Formula I: ##STR1## wherein: R.sub.1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; PA1 R.sub.2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; PA1 R.sub.3 is hydrogen or lower alkyl of up to 6 carbon atoms; PA1 R.sub.4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--; PA1 X is a valency bond, --CH.sub.2, oxygen or sulfur; PA1 Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; PA1 R.sub.5 and R.sub.6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a --CONH.sub.2 -- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or PA1 R.sub.5 and R.sub.6 together represent methylenedioxy; or a pharmaceutically acceptable salt thereof, for inhibition of pro…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.