Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ACE
US5644055A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 20, 1995 |
| Grant date | Jul 1, 1997 |
| Priority date | — |
| Expiry date | Dec 20, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are the compounds of formula I ##STR1## wherein X represents oxo, one hydroxy or lower alkoxy and one hydrogen, or two hydrogens; PA1 R.sub.a and R.sub.b independently represent hydrogen, hydroxy, lower alkoxy, nitro, amino or halogen; or R.sub.a and R.sub.b on adjacent carbons taken together represent lower alkylenedioxy; PA1 R.sub.c represents hydrogen, lower alkyl or aryl-lower alkyl; PA1 R represents hydrogen or acyl; PA1 R.sub.1 represents hydrogen, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, biaryl, biaryl-lower alkyl or trifluoromethyl; PA1 R.sub.2 represents hydrogen or lower alkyl; or R.sub.1 and R.sub.2 together with the carbon to which they are attached represent cycloalkylene or benzo-fused cycloalkylene; PA1 m represents one or two; PA1 n represents zero or one; PA1 COOR.sub.3 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; disulfide derivatives formed from said compounds wherein R is hydrogen; PA1 and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for preparation of said compounds; intermediates; and methods of treating disorder…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.