Genetically engineered mice containing alterations in the MHC class II genes

US5644065A · kind A · utility

Assignees

• Bristol-Myers Squibb Company · US
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE LOUIS PASTEUR · FR

Inventors

• Christophe Benoist · Strasbourg, FR
• Diane Mathis · Brookline, US
• Dominic Cosgrove · Omaha, US

Key dates

• Filing date: Oct 3, 1994
• Grant date: Jul 1, 1997
• Expiry date: Oct 3, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2517/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides mice which are deficient in the normal expression of one or more MHC class II genes, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous, homozygous or chimeric for such deficiency, as well as to the use of any of the above, especially in situations where the absence of at least one MHC gene, or the normal expression thereof, is desirable.