Multilayered controlled release pharmaceutical dosage form

US5645858A · kind A · utility

Assignee

• Ortho Pharmaceutical Corporation · US

Inventors

• Pramod M. Kotwal · Blue Bell, US
• Stephen A. Howard · Flemington, US

Key dates

• Filing date: Dec 7, 1995
• Grant date: Jul 8, 1997
• Expiry date: Dec 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5078
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate release to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the multilayered coated particle.