Sterol modified oligonucleotide duplexes having anticancer activity

US5646126A · kind A · utility

Assignees

• Epoch Pharmaceuticals, Inc. · US
• Yale University · US

Inventors

• Yung-Chi Cheng · Woodbridge, US
• Eugeny A. Lukhtanov · Bothell, US
• Rich B. Meyer, Jr. · Bothell, US
• Balakrishna S. Pai · New Haven, US
• Michael W. Reed · Lake Forest Park, US
• James Zhou · New Haven, US

Key dates

• Filing date: Feb 28, 1994
• Grant date: Jul 8, 1997
• Expiry date: Feb 28, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/68
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Oligonucleotides having approximately 8 to 18 nucleotide units and a 3'-tail which includes asteroid structure attached to the 3'-end through the A ring of the steroid skeleton and which form substantially stable duplexes at physiological temperature, have selective cytotoxic activity against certain tumor cell lines.