Polyamine derivatives of 1-aminoindan

US5646188A · kind A · utility

Assignee

• TEVA PHARMACEUTICAL INDUSTRIES, LTD. · IL

Inventors

• Gad Gilad · Givatayim, IL
• Varda Gilad · Givatayim, IL
• Jeffrey Sterling · Jerusalem, IL
• Yaacov Herzig · Raanana, IL
• David Lerner · Akron, US
• Alex Veinberg · Rehovot, IL
• Isaac Milman · 'Anata, IL
• Nina Finkelstein · Herzliya, IL

Key dates

• Filing date: Jul 5, 1995
• Grant date: Jul 8, 1997
• Expiry date: Jul 5, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of general formula I ##STR1## wherein n is 1 or 2; R.sub.1 and R.sub.2 are each independently hydrogen, hydroxy, substituted or unsubstituted C.sub.1-4 alkyl, substituted or unsubstituted C.sub.1-4 alkoxy or halogeno; PA1 R.sub.5 is hydrogen, substituted or unsubstituted C.sub.1-4 alkyl, amino or NR.sub.6 R.sub.7 ; PA1 R.sub.3, R.sub.4, R.sub.6 and R.sub.7 are each independently hydrogen or (CH.sub.2).sub.m --[NH(CH.sub.2).sub.x ].sub.y --NHR.sub.11 wherein m is from 0-5, y is from 0-5 and each x is independently from 1-5 and R.sub.11 is hydrogen or C(NH)NH.sub.2 ; provided that when R.sub.3 and R.sub.4 are both hydrogen, R.sub.5 is amino or NR.sub.6 R.sub.7 ; pharmaceutically acceptable salts and optically active isomers thereof.