Palladium catalyzed vinylic substitution reactions with 2-substituted-pyridines
US5646286A · kind A · utility
1Cited by
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12Claims
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Assignee
Inventors
Key dates
| Filing date | May 26, 1995 |
| Grant date | Jul 8, 1997 |
| Priority date | — |
| Expiry date | May 26, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/65
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention involves a coupling reaction involving an organo-metallic catalyst, preferably a palladium catalyst involving reacting 2-halo-3-hydroxy-6-hydroxymethylpyridine, acrylic acid or its alkali metal salt and benzyl or a phenylalkyl derivative in presence of a dipolar aprotic solvent producing none other than the expected 2-propenoate-3-benzyl or phenylalkylether-6-hydroxymethyl-pyridine product. Said products are converted into medicaments useful for treating psoriasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.